import filecmp import tempfile import os a = tempfile.NamedTemporaryFile(delete=False, mode="w", encoding="utf-8") a.write("hello") a.close() b = tempfile.NamedTemporaryFile(delete=False, mode="w", encoding="utf-8") b.write("hello") b.close() print(filecmp.cmp(a.name, b.name, shallow=False)) os.remove(a.name); os.remove(b.name)